Wednesday, August 20 Updated: September 1, 1:57 PM ET
Southern Supremacy
The Colts have lost three straight games to Tennessee.
Do or die in Week 2? Perhaps for the Colts, who take on division rival Tennessee in one of John Clayton's 10 can't-miss games of 2003. The AFC South foes are both in the top 10 of ESPN.com's Power Rankings. As for long-term predictions, eight of our experts pick the Titans to make Super Bowl XXXVIII.